Hepatoid Adenocarcinoma of the Retroperitoneal Cavity: a Case Report

  • Stephanie Marisca
  • Ening Krisnuhoni
Keywords: Key words: hepatoid adenocarcinoma, retroperitoneal cavity, immunohistochemistry.


Hepatoid adenocarcinoma (HAC) is a rare type of
extrahepatic adenocarcinoma with clinicopathological features
resembling hepatocellular carcinoma (HCC). The most common
site of HAC is the stomach, although it has also been reported in
various organs, such as gastrointestinal tract, ovary, pancreas,
lung, kidney, uterus, and urinary bladder. The minimum histological
criteria of HAC are the abundant eosinophilic cytoplasm and the
evidence of alpha-fetoprotein (AFP) production, although the
results are not always positive.HAC has an extremely poor
prognosis with only a few cases reported. We report a case of a 56-
year-old woman who came to Cipto Mangunkusumo Hospital with
chief complaints of lower abdominal pain and enlargement. The
abdominopelvic ultrasonography (USG) and computed tomography
(CT) scan showed tumor mass in lower abdominal and pelvic area
without any significant abnormalities in other abdominal organs.
Microscopically, the tumor was first diagnosed as poorly
differentiated carcinoma, but after reevaluation and immunohistochemistry (IHC) staining results suggested HAC of the
retroperitoneal cavity.